Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols
Abstract Background Notwithstanding the efforts of direct-acting antivirals (DAAs) for the treatment of chronically infected hepatitis C virus (HCV) patients, concerns exist regarding the emergence of resistance-associated substitutions Ball - Glove First Base - Junior (RAS) related to therapy failure.Sanger sequencing is still the reference techni